[KARE/KANOJO]

Both are pronouns. 'KARE' means 'HE', 'KANOJO' means 'SHE'.

'KARE(He) WA(is) WATASHI(my) NO TOMODACHI(friend) DESU'.

But if you said it as a noun, 'KARE' would mean 'BOYFRIEND' and 'KANOJO' would mean 'GIRLFRIEND'. Actually we don't use them as pronoun, because we often omit the subject. 'WATASHI NO KARE DESU' means 'He is my boyfriend'.